NCI Award Acknowledgment Statement

Center authors are required to acknowledge NCI support when reporting work supported by our award. Please use the statement shown below.

The work described was supported by the Center on the Physics of Cancer Metabolism through Award Number 1U54CA210184-01 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

List of Publications

Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific reports. 2017 October 30; 7(1):14327. PubMed PMID: 29085021; PubMed Central PMCID: PMC5662654.

Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific reports. 2017 October 30; 7(1):14327. PubMed PMID: 29085021; PubMed Central PMCID: PMC5662654.

Shah P, Wolf K, Lammerding J. Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability. Trends Cell Biol.2017 Aug;27(8):546-555. doi: 10.1016/j.tcb.2017.02.008. Epub 2017 Mar 9 PubMed PMID: 28285738

Northey JJ, Przybyla L, Weaver VM. Tissue Force Programs Cell Fate and Tumor Aggression. Cancer discovery. 2017 November;7 (11):1224-1237. PubMed PMID: 29038232; PubMed Central PMCID: PMC5679454.

Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Molecular biology of the cell. 2017 November 1; 28(22):2958-2977. PubMed PMID: 28877984; PubMed Central PMCID: PMC5662256.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.  Integrin-Mediated Traction Force Enhances Paxillin Molecular Associations and Adhesion Dynamics That Increase the Invasiveness of Tumor Cells into a Three-Dimensional Extracellular Matrix. 2017. Molecular Biology of the Cell. 28(11):1467-1488. PubMed PMID: 28381423.

Iyengar NM, Brown KA, Zhou XK, Gucalp A, Subbaramaiah K, Giri DD, Zahid H, Bhardwaj P, Wendel NK, Falcone DJ, Wang H, Williams S, Pollak M, Morrow M, Hudis CA, Dannenberg AJ. Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index. 2017. Cancer Prevention Research (Philadelphia, Pa.); 10(4):235-243. PubMed PMID: 28270386; PubMed Central PMCID: PMC5380584.

Hamilton BS, Wilson JD, Shumakovich MA, Fisher AC, Brooks JC, Pontes A, Naran R, Heiss C, Gao C, Kardish R, Heimburg-Molinaro J, Azadi P, Cummings RD, Merritt JH, DeLisa MP. A library of chemically defined human N-glycans synthesized from microbial oligosaccharide precursors. Scientific reports. 2017 November 21;7(1):15907. PubMed PMID: 29162910; PubMed Central PMCID: PMC5698433.

Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K Pathway in Human Disease. Cell. 2017 August 10; 170(4):605-635. PubMed PMID: 28802037; PubMed Central PMCID: PMC5726441.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 January 25; 553(7689):467-472. PubMed PMID: 29342134; PubMed Central PMCID: PMC5785464.

Choi S, Friedrichs J, Song YH, Werner C, Estroff LA, Fischbach C. Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration. Biomaterials. 2018 May 7. PubMed PMID: 29759731.

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL. PIK3CA; C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PIK3 Inhibitors. Clinical cancer research: an official journal of the American Association for Cancer Research. 2018 March 15; 24(6):1426-1435. PubMed PMID: 29284706; PubMed Central PMCID: PMC5856622.

DelNero P, Hopkins BD, Cantley LC, Fischbach C. Cancer metabolism gets physicalSci Transl Med. 2018 May 23; 10(442). pii: eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Review. PMID: 29794058

Druso JE, Fischbach C. Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer. Trends in cancer. 2018 April; 4(4):271-273. PubMed PMID: 29606310; PubMed Central PMCID: PMC5884448.

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2018 January 23; 115(4):E743-E752. PubMed PMID: 29311302; PubMed Central PMCID: PMC5789923.

Iyengar NM, Chen IC, Zhou XK, Giri DD, Falcone DJ, Winston LA, Wang H, Williams S, Lu YS, Hsueh TH, Cheng AL, Hudis CA, Lin CH, Dannenberg AJ. Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Cancer prevention research (Philadelphia, Pa.). 2018 April; 11(4):227-236. PubMed PMID: 29222346; PubMed Central PMCID: PMC5882588.

Zahid H, Subbaramaiah K, Iyengar NM, Zhou XK, Chen IC, Bhardwaj P, Gucalp A, Morrow M, Hudis CA, Dannenberg AJ, Brown KA. Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link. Int J Obes (Lond). 2018 Apr;42(4):711-720. doi: 10.1038/ijo.2017.273. Epub 2017 Nov 6. PMID: 29104286.

Kunitake JAMR, Choi S, Nguyen KX, Lee MM, He F, Sudilovsky D, Morris PG, Jochelson MS, Hudis CA, Muller DA, Fratzl P, Fischbach C, Masic A, Estroff LA. Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas. Journal of structural biology. 2018 April; 202(1):25-34. PubMed PMID: 29221896; PubMed Central PMCID: PMC5835408.

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Cancer discovery. 2018 March;8(3):354-369. PubMed PMID: 29203461; PubMed Central PMCID: PMC5907916.

Lourenço BN, Springer NL, Ferreira D, Oliveira C, Granja PL, Fischbach C. CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling. Integrative biology: quantitative biosciences from nano to macro. 2018 March 1; 10(3):145-158. PubMed PMID: 29450424.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular cell. 2018 May 3; 70(3):531-544.e9. PubMed PMID: 29727621.

MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A. Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Leukemia & lymphoma. 2018 March 23;1-11. PubMed PMID: 29569971.

Northcott JM, Dean IS, Mouw JK, Weaver VM. Feeling Stress: The Mechanics of Cancer Progression and Aggression. Frontiers in cell and developmental biology. 2018; 6:17. PubMed PMID: 29541636; PubMed Central PMCID: PMC5835517.

Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R. Excess area dependent scaling behavior of nano-sized membrane tethers. Physical biology. 2018 January 11; 15(2):026002. PubMed PMID: 29116056; PubMed Central PMCID: PMC5832653.

Shurer CR, Colville MJ, Gupta VK, Head SE, Kai F, Lakins JN, and Paszek MJ, Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors. ACS Biomaterials Science & Engineering. 4(2):388-399. 2018 Feb 12. PubMed PMID: 29805991

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & development. 2018 February 1; 32(3-4):244-257. PubMed PMID: 29483153; PubMed Central PMCID: PMC5859966.

van Helvert S, Storm C, Friedl P. Mechanoreciprocity in cell migration. Nature cell biology. 2018 January; 20(1):8-20. PubMed PMID: 29269951; PubMed Central PMCID: PMC5943039.

Elacqua JJ, McGregor AL, Lammerding J. Automated analysis of cell migration and nuclear envelope rupture in confined environments. PLoS One. 2018. 13(4): e0195664. PubMed PMID: 29649271

Vidavsky N, Kunitake JA, Chiou AE, Northrup PA, Porri TJ, Ling L, Fischbach C, Estroff LA, Studying biomineralization pathways in a 3D culture model of breast cancer microcalcifications. Biomaterials. 2018 Oct;179:71-82. doi: 10.1016/j.biomaterials.2018.06.030. PubMed PMID: 29980076

Yadav S, Feigelson S, Roncato F, Antman-Passig M, Shefi O, Lammerding J, Alon R. Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers. J Leuk Biol. 2018 Mar 30. doi: 10.1002/JLB.3HI1217-488R. [Epub ahead of print]2018. PubMed PMID: 29601096

Latifkar, A., Ling, L., Hingorani, A., Clement, A., Zhang, X., Hartman, J., Fischbach, C., Lin, H., Cerione, R.A., and Antonyak, M..A. (2018) Loss of Sirtuin 1 alters the secretome of breast cancer cells by impairing lysosomal integrity. Developmental Cell. 2019 May 6;49(3):393-408.e7. PubMed PMID: 30982660

White FM, Gatenby RA, Fischbach C. The Physics of Cancer. Cancer research. 2019 May 1;79(9):2107-2110. PubMed PMID: 31018939; PubMed Central PMCID:

Zhang Q, Tamashunas AC, Agrawal A, Torbati M, Katiyar A, Dickinson RB, Lammerding J, Lele TP. Local, transient tensile stress on the nuclear membrane causes membrane rupture. Molecular biology of the cell. 2019 March 21;30(7):899-906. PubMed PMID: 30566037.

Beunk L, Brown K, Nagtegaal I, Friedl P, Wolf K. Cancer invasion into musculature: Mechanics, molecules and implications. Seminars in cell & developmental biology. 2018 September 4. PubMed PMID: 3009945; PubMed Central PMCID: PMC6399078.

Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin  MA, Mukherjee S, Cantley LC. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. 2018 Aug .;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4. Erratum in: Nature. 2018 Aug 29; PubMed PMID: 30051890; PMCID: PMC6197057.

Quail DF and Dannenberg AJ. 2019. The obese adipose tissue microenvironment in cancer development and progression. Nat. Rev. Endocrinol. 15:139-154. PMID: 30459447 PubMed Central PMCID: PMC6374176

Iyengar NM, Arthur R, Manson JE, Chlebowski RT, Kroenke CH, Peterson L, Cheng TD, Feliciano EC, Lane D, Luo J, Nassir R, Pan K, Wassertheil-Smoller S, Kamensky V, Rohan T and Dannenberg AJ. 2019. Association of body fat and risk of breast cancer in postmenopausal women with normal body mass index: a secondary analysis of a randomized clinical trial and observational study. JAMA Oncol. 5: 155-163. PubMed PMID: 30520976

Greenlee H, Shi Z, Hibshoosh H, Giri D, Ahmed A, Williams S, Falcone DJ, Winston LA, Zhou XK, Hudis C, Hershman D, Dannenberg AJ and Iyengar NM. 2019. Obesity and breast inflammation among Hispanic/Latina breast cancer patients. Cancer Prev. Res. 12:21-30. PubMed PMID: 30404870

Bakhoum SF, Cantley LC. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment. Cell. 2018 Sep 6;174(6):1347-1360. doi: 10.1016/j.cell.2018.08.027. PubMed PMID: 30193109; PMCID: PMC6136429.

Subbaramaiah K, Iyengar NM, Morrow M, Elemento O, Zhou XK, Dannenberg AJ. Prostaglandin E<sub>2</sub> down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. The Journal of biological chemistry. 2019 January 4;294(1):361-371. PubMed PMID: 30409902; PubMed Central PMCID: PMC6322870

Zheng Y, Cantley LC. Toward a better understanding of folate metabolism in health and disease. The Journal of experimental medicine. 2019 February 4;216(2):253-266. PubMed PMID: 30587505; PubMed Central PMCID: PMC6363433

Gandhi JG, Koch DL, Paszek MJ. Equilibrium Modeling of the Mechanics and Structure of the Cancer Glycocalyx. Biophysical journal. 2019 February 19;116(4):694-708. PubMed PMID: 30736980; PubMed Central PMCID: PMC6382957

Cox EC, Thornlow DN, Jones MA, Fuller JL, Merritt JH, Paszek MJ, Alabi CA, DeLisa MP. Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody-Drug Conjugate. Cancer research. 2019 April 15;79(8):1810-1821. PubMed PMID: 30808675; PubMed Central PMCID: PMC6467748

Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O’Donnell JP, Yin R, Pedram K, Möckl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ. Physical Principles of Membrane Shape Regulation by the Glycocalyx. Cell. 2019 April 30. PubMed PMID: 31056282

Ngo B, Van Riper JM, Cantley LC, Yun J. Targeting cancer vulnerabilities with high-dose vitamin C. Nature reviews. Cancer. 2019 May;19(5):271-282. PubMed PMID: 30967651; PubMed Central PMCID: PMC6526932

Shurer CR, Head SE, Goudge MC, Paszek MJ. Mucin-coating technologies for protection and reduced aggregation of cellular production systems. Biotechnology and bioengineering. 2019 May;116(5):994-1005. PubMed PMID: 30636317

Zheng Y, Ramsamooj S, Li Q, Johnson JL, Yaron TM, Sharra K, Cantley LC. Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Scientific reports. 2019 March 12;9(1):4190. PubMed PMID: 30862944; PubMed Central PMCID: PMC6414673

Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ. Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. Journal of proteome research. 2019 May 3;18(5):2078-2087. PubMed PMID: 30964683; PubMed Central PMCID: PMC6499638

Kai F, Drain AP, Weaver VM. The Extracellular Matrix Modulates the Metastatic Journey. Developmental cell. 2019 May 6;49(3):332-346. PubMed PMID: 31063753; PubMed Central PMCID: PMC6527347

Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC. PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell reports. 2019 May 14;27(7):1991-2001.e5. PubMed PMID: 31091439

Shurer CR, Wang Y, Feeney E, Head SE, Zhang VX, Su J, Cheng Z, Stark MA, Bonassar LJ, Reesink HL, Paszek MJ. Stable recombinant production of codon-scrambled lubricin and mucin in human cells. Biotechnology and bioengineering. 2019 June;116(6):1292-1303. PubMed PMID: 30684357