NCI Award Acknowledgment Statement

Center authors are required to acknowledge NCI support when reporting work supported by our award. Please use the statement shown below.

The work described was supported by the Center on the Physics of Cancer Metabolism through Award Number 1U54CA210184-01 from the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute or the National Institutes of Health.

List of Publications

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. 2018 January 25; 553(7689):467-472. PubMed PMID: 29342134; PubMed Central PMCID: PMC5785464.

Choi S, Friedrichs J, Song YH, Werner C, Estroff LA, Fischbach C. Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration. Biomaterials. 2018 May 7. PubMed PMID: 29759731.

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL. PIK3CA; C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PIK3 Inhibitors. Clinical cancer research: an official journal of the American Association for Cancer Research. 2018 March 15; 24(6):1426-1435. PubMed PMID: 29284706; PubMed Central PMCID: PMC5856622.

DelNero P, Hopkins BD, Cantley LC, Fischbach C. Cancer metabolism gets physical. Sci Transl Med. 2018 May 23; 10(442). pii: eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Review. PMID: 29794058

Druso JE, Fischbach C. Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer. Trends in cancer. 2018 April; 4(4):271-273. PubMed PMID: 29606310; PubMed Central PMCID: PMC5884448.

Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K Pathway in Human Disease. Cell. 2017 August 10; 170(4):605-635. PubMed PMID: 28802037; PubMed Central PMCID: PMC5726441.

Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2018 January 23; 115(4):E743-E752. PubMed PMID: 29311302; PubMed Central PMCID: PMC5789923.

Hamilton BS, Wilson JD, Shumakovich MA, Fisher AC, Brooks JC, Pontes A, Naran R, Heiss C, Gao C, Kardish R, Heimburg-Molinaro J, Azadi P, Cummings RD, Merritt JH, DeLisa MP. A library of chemically defined human N-glycans synthesized from microbial oligosaccharide precursors. Scientific reports. 2017 November 21;7(1):15907. PubMed PMID: 29162910; PubMed Central PMCID: PMC5698433.

Iyengar NM, Chen IC, Zhou XK, Giri DD, Falcone DJ, Winston LA, Wang H, Williams S, Lu YS, Hsueh TH, Cheng AL, Hudis CA, Lin CH, Dannenberg AJ. Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Cancer prevention research (Philadelphia, Pa.). 2018 April; 11(4):227-236. PubMed PMID: 29222346; PubMed Central PMCID: PMC5882588.

Iyengar NM, Brown KA, Zhou XK, Gucalp A, Subbaramaiah K, Giri DD, Zahid H, Bhardwaj P, Wendel NK, Falcone DJ, Wang H, Williams S, Pollak M, Morrow M, Hudis CA, Dannenberg AJ. Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index. Cancer Prevention Research (Philadelphia, Pa.); 10(4):235-243. PubMed PMID: 28270386; PubMed Central PMCID: PMC5380584.

Kaushik S, Pickup MW, Weaver VM. From Transformation to Metastasis: Deconstructing the Extracellular Matrix in Breast Cancer. Cancer Metastasis Reviews; 35(4):655-667. PubMed PMID: 27914000; PubMed Central PMCID: PMC5215979.

Kunitake JAMR, Choi S, Nguyen KX, Lee MM, He F, Sudilovsky D, Morris PG, Jochelson MS, Hudis CA, Muller DA, Fratzl P, Fischbach C, Masic A, Estroff LA. Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas. Journal of structural biology. 2018 April; 202(1):25-34. PubMed PMID: 29221896; PubMed Central PMCID: PMC5835408.

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. Cancer discovery. 2018 March;8(3):354-369. PubMed PMID: 29203461; PubMed Central PMCID: PMC5907916.

Lourenço BN, Springer NL, Ferreira D, Oliveira C, Granja PL, Fischbach C. CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling. Integrative biology: quantitative biosciences from nano to macro. 2018 March 1; 10(3):145-158. PubMed PMID: 29450424.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular cell. 2018 May 3; 70(3):531-544.e9. PubMed PMID: 29727621.

MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A. Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Leukemia & lymphoma. 2018 March 23;1-11. PubMed PMID: 29569971.

Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM.  Integrin-Mediated Traction Force Enhances Paxillin Molecular Associations and Adhesion Dynamics That Increase the Invasiveness of Tumor Cells into a Three-Dimensional Extracellular Matrix. Molecular Biology of the Cell; 28(11):1467-1488. PubMed PMID: 28381423.

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue Mechanics Promote IDH1-Dependent HIF1α-Tenascin C Feedback to Regulate Glioblastoma Aggression. Nature Cell Biology; 18(12):1336-1345. PubMed PMID: 27820599; PubMed Central PMCID: PMC5361403.

Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Hannachi EI, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM. α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Molecular biology of the cell. 2017 November 1; 28(22):2958-2977. PubMed PMID: 28877984; PubMed Central PMCID: PMC5662256.

Northcott JM, Dean IS, Mouw JK, Weaver VM. Feeling Stress: The Mechanics of Cancer Progression and Aggression. Frontiers in cell and developmental biology. 2018; 6:17. PubMed PMID: 29541636; PubMed Central PMCID: PMC5835517.

Northey JJ, Przybyla L, Weaver VM. Tissue Force Programs Cell Fate and Tumor Aggression. Cancer discovery. 2017 November;7 (11):1224-1237. PubMed PMID: 29038232; PubMed Central PMCID: PMC5679454.

Ramakrishnan N, Sreeja KK, Roychoudhury A, Eckmann DM, Ayyaswamy PS, Baumgart T, Pucadyil T, Patil S, Weaver VM, Radhakrishnan R. Excess area dependent scaling behavior of nano-sized membrane tethers. Physical biology. 2018 January 11; 15(2):026002. PubMed PMID: 29116056; PubMed Central PMCID: PMC5832653.

Shah P, Wolf K, Lammerding J. Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability. Trends in Cell Biology. PubMed PMID: 28285738.

Shurer CR, Colville MJ, Gupta VK, Head SE, Kai F, Lakins JN, and Paszek MJ, Genetically Encoded Toolbox for Glycocalyx Engineering: Tunable Control of Cell Adhesion, Survival, and Cancer Cell Behaviors. ACS Biomaterials Science & Engineering Article ASAP. DOI: 10.1021/acsbiomaterials.7b00037

Song YH, Warncke C, Choi SJ, Choi S, Chiou AE, Ling L, Liu HY, Daniel S, Antonyak MA, Cerione RA, Fischbach C. Breast Cancer-Derived Extracellular Vesicles Stimulate Myofibroblast Differentiation and Pro-Angiogenic Behavior of Adipose Stem Cells. Matrix Biology: Journal of the International Society for Matrix Biology.; 60-61:190-205. PubMed PMID: 27913195; PubMed Central PMCID: PMC5438891.

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & development. 2018 February 1; 32(3-4):244-257. PubMed PMID: 29483153; PubMed Central PMCID: PMC5859966.

Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific reports. 2017 October 30; 7(1):14327. PubMed PMID: 29085021; PubMed Central PMCID: PMC5662654.

Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific reports. 2017 October 30; 7(1):14327. PubMed PMID: 29085021; PubMed Central PMCID: PMC5662654.

van Helvert S, Storm C, Friedl P. Mechanoreciprocity in cell migration. Nature cell biology. 2018 January; 20(1):8-20. PubMed PMID: 29269951; PubMed Central PMCID: PMC5943039.